Klasifikasi obat-obatan antidysrhythmia

 

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Note-8. Klasifikasi obat-obatan antidysrhythmia

VAUGHAN WILLIAMS mengklasifikasikan obat-obatan ANTIDYSRHYTHMIC berdasarkan kelas-kelas sebagai berikut:

Class I: membrane-stabilizing drugs; fast sodium channel blockers

    Ia: ↑ blockade of sodium channel, delay repolarization, ↑ action potential duration

Quinidine, disopyramide, procainamide

    Ib: ↑ blockade of sodium channel, accelerate repolarization, ± action potential duration

Lidocaine, phenytoin

    Ic: ↑↑↑ blockade of sodium channel, ± repolarization; also suppress reentry

Flecainide, propafenone

Class II: beta-blocking drugs

All beta blockers

Class III: drugs whose principal effect on cardiac tissue is to ↑ action potential duration

Amiodarone, dronedarone, sotalol,* ibutilide, dofetilide

Class IV: calcium channel blockers

Verapamil, diltiazem

Other: antidysrhythmic drugs that have the properties of several classes and therefore cannot be placed in one particular class

Digoxin, adenosine

↑, Increase; ±, increase or decrease.

* Sotalol also has class II properties.

From Lilley.